Virus
Molluscum contagiosum virus
Umbilicated papules from a poxvirus
muh-LUS-kum kun-tay-jee-OH-sum VY-rus
High-yield clue
Small flesh-colored papules with a central dimple (umbilication) and molluscum bodies are the signature clue.
Overview
A large double-stranded DNA poxvirus that replicates in the cytoplasm of skin cells and produces distinctive dome-shaped umbilicated papules, a classic dermatologic teaching lesion.
Classification
- DNA virus
- Double-stranded DNA
- Cytoplasmic replication
- Family Poxviridae, genus Molluscipoxvirus
Lab & identification clues
- Molluscum (Henderson-Paterson) inclusion body concept
- Central umbilication morphology vocabulary
- Cytoplasmic replication distinction
- Skin-scraping cytology concept
Associations
- Skin-to-skin and fomite contact spread
- Common in children and via autoinoculation
- Extensive lesions in immunocompromised hosts
- Study contrast with warts (HPV)
Commonly confused with
- Human papillomavirus warts
- Varicella-zoster vesicles
Frequently asked questions
What is Molluscum contagiosum virus?
A large double-stranded DNA poxvirus that replicates in the cytoplasm of skin cells and produces distinctive dome-shaped umbilicated papules, a classic dermatologic teaching lesion.
What are the lab clues for Molluscum contagiosum virus?
Lab clues for Molluscum contagiosum virus include Molluscum (Henderson-Paterson) inclusion body concept, Central umbilication morphology vocabulary, Cytoplasmic replication distinction, and Skin-scraping cytology concept.
What is Molluscum contagiosum virus commonly confused with?
Molluscum contagiosum virus is commonly confused with Human papillomavirus warts and Varicella-zoster vesicles.
Original student-study summary. Sources checked: OpenStax Microbiology 2e, NCBI Bookshelf Medical Microbiology, and CDC topic pages where applicable; reviewed 2026-06. Educational only; no diagnosis, treatment, dosing, or specimen-handling guidance.