Antimicrobial
Glycylcyclines (tigecycline)
Tetracycline derivative evading tet resistance
gly-sil-SY-kleens
High-yield clue
Tigecycline binds the 30S ribosome more tightly than tetracyclines, so it overcomes tet efflux pumps and ribosomal protection.
Overview
A tetracycline-derived protein-synthesis class represented by tigecycline, studied for a bulky D-9 side chain that lets it evade classic tetracycline resistance mechanisms.
Classification
- Protein-synthesis inhibitor
- Binds 30S ribosomal subunit
- Bacteriostatic
- Broad Gram-positive/Gram-negative/anaerobe spectrum
Lab & identification clues
- Evades TetB efflux pump vocabulary
- Overcomes ribosomal protection (tetM/tetO) concept
- Limited activity against Pseudomonas and Proteus
Associations
- Multidrug-resistant organism reserve vocabulary
- Low serum concentrations (tissue distribution) concept
- Derived from minocycline scaffold
Commonly confused with
- Tetracyclines
- Chloramphenicol
Frequently asked questions
What is Glycylcyclines (tigecycline)?
A tetracycline-derived protein-synthesis class represented by tigecycline, studied for a bulky D-9 side chain that lets it evade classic tetracycline resistance mechanisms.
What is the high-yield clue for Glycylcyclines (tigecycline)?
Tigecycline binds the 30S ribosome more tightly than tetracyclines, so it overcomes tet efflux pumps and ribosomal protection.
What is Glycylcyclines (tigecycline) associated with?
Glycylcyclines (tigecycline) is associated with Multidrug-resistant organism reserve vocabulary, Low serum concentrations (tissue distribution) concept, and Derived from minocycline scaffold.
What is Glycylcyclines (tigecycline) commonly confused with?
Glycylcyclines (tigecycline) is commonly confused with Tetracyclines and Chloramphenicol.
Original mechanism summary for microbiology study. Sources checked: CDC antimicrobial-resistance guidance, NCBI Bookshelf Medical Microbiology, and standard coursework frameworks; reviewed 2026-06. Covers class, mechanism, and resistance vocabulary only; no prescribing, dosing, or patient-specific treatment guidance.